N-Methyl acetoacetylamide
N-Methyl acetoacetylamide
CAS: 20306-75-6
Molecular Formula: C5H9NO2
N-Methyl acetoacetylamide - Names and Identifiers
| Name | N-Methyl acetoacetylamide |
| Synonyms | N-Methylacetamid Dimethylformamide Arbidol Impurity 7 AcetoN-methylacetamide N-Methylacetoacetamide n-methyl-3-oxo-butanamid N-ACETOACETYLMETHYLAMINE N-methyl-3-oxobutanamide N-Methyl acetoacetylamide Acetoacet-monomethylamide Butanamide,N-methyl-3-oxo- |
| CAS | 20306-75-6 |
| EINECS | 243-723-9 |
| InChI | InChI=1/C5H9NO2/c1-4(7)3-5(8)6-2/h3H2,1-2H3,(H,6,8) |
N-Methyl acetoacetylamide - Physico-chemical Properties
| Molecular Formula | C5H9NO2 |
| Molar Mass | 115.13 |
| Density | 1.069 |
| Melting Point | -3 °C |
| Boling Point | 106°C |
| Flash Point | 105 °C |
| Water Solubility | hydrolysis |
| Solubility | hydrolysis |
| Vapor Presure | 0.00403mmHg at 25°C |
| Appearance | clear liquid |
| Color | Light yellow to Yellow to Orange |
| pKa | 12.79±0.46(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.4325-1.4345 |
| Physical and Chemical Properties | Acetyl methyl amine is white needle-like crystals, m. P. 47~49 ℃, soluble in ether, acetone. |
| Use | Used as pesticide intermediates, can also be used as feed additives |
N-Methyl acetoacetylamide - Risk and Safety
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
N-Methyl acetoacetylamide - Upstream Downstream Industry
| Raw Materials | Methylamine diketene Methylamine |
| Downstream Products | Monocrotophos |
N-Methyl acetoacetylamide - Nature
Open Data Verified Data
White needle-like crystals. The melting point was 47-49 °c. Soluble in ether, acetone.
Last Update：2024-01-02 23:10:35
N-Methyl acetoacetylamide - Preparation Method
Open Data Verified Data
results from the interaction of diketene with methylamine.
Last Update：2022-01-01 10:36:03
N-Methyl acetoacetylamide - Use
Open Data Verified Data
This product is chlorinated to a-Chloroacetyl methyl amine, can be used for the production of pesticide organophosphorus pesticide monocrotophos; Can also be used for the preparation of 1,3,5 pyrazolone, and then the preparation of analgin drug.
Last Update：2022-01-01 10:36:03
N-Methyl acetoacetylamide - Safety
Open Data Verified Data
200kg plastic barrel was used for packaging.
Last Update：2022-01-01 10:36:04
N-Methyl acetoacetylamide - Reference Information
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| Uses | Acetylmethamine is an important intermediate for the synthesis of organophosphorus insecticide monocrotophos. It can also be used to prepare the drug analgin. This product is chlorinated to obtain α-chloroacetylmethamine, which can be used to produce the pesticide organophosphorus insecticide monocrotophos; it can also be used to make 1,3, 5-pyrazolone, and then to make analgin drugs. Used as a pesticide intermediate and also as a feed additive |
| Production method | is obtained by the reaction of diketene and methylamine. The methylamine aqueous solution is put into a glass-lined reaction kettle, stirred and cooled at -5 ℃, diketene is added dropwise, the temperature is controlled at 0-2 ℃, the ratio of diketene to methylamine is 1:1, after dropping, methylamine is added to the pH of the reaction solution to 7-8, and stirring is continued for half an hour. Distillate under reduced pressure below 50°C to obtain acetylmethamine. The preparation method is prepared by the reaction of diketene and methylamine aqueous solution at low temperature. 40% methylamine is put into the enamel kettle, cooled to 0 ℃ under stirring, and then slowly added with newly steamed diketene (content above 95%) under cooling. The reaction exotherm, control the droplet acceleration, so that the reaction temperature does not exceed 20 ℃, about 3 hours to complete. After 30min of heat preservation, whether the conversion of diketene is complete is detected, and then the reaction is stopped to obtain acetylmethylamine with a content of about 65% and a yield of more than 96%. |
Last Update：2024-04-09 19:05:07
Supplier List
View History
Raw Materials for N-Methyl acetoacetylamide
Downstream Products for N-Methyl acetoacetylamide